3D Cultivation Techniques for Primary Human Hepatocytes

3D Cultivation Techniques for Primary Human Hepatocytes

One of the main challenges in drug development is the prediction of in vivo toxicity based on in vitro data. The standard cultivation system for primary human hepatocytes is based on monolayer cultures, even if it is known that these conditions result in a loss of hepatocyte morphology and of liver-...

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Bibliographic Details
Main Authors: Anastasia Bachmann, Matthias Moll, Eric Gottwald, Cordula Nies, Roman Zantl, Helga Wagner, Britta Burkhardt, Juan J. Martínez Sánchez, Ruth Ladurner, Wolfgang Thasler, Georg Damm, Andreas K. Nussler
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:Microarrays
Subjects:
primary human hepatocytes
three-dimensional (3D) cell culture
two-dimensional (2D) cell culture
in vitro model
hydrogels
scaffolds
drug-induced hepatotoxicity
long-term culture
Online Access:http://www.mdpi.com/2076-3905/4/1/64

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http://www.mdpi.com/2076-3905/4/1/64

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