The physiological functions of iron regulatory proteins in iron homeostasis - an update

The physiological functions of iron regulatory proteins in iron homeostasis - an update

Iron regulatory proteins (IRPs) regulate the expression of genes involved in iron metabolism by binding to RNA stem-loop structures known as iron responsive elements (IREs) in target mRNAs. IRP binding inhibits the translation of mRNAs that contain an IRE in the 5’untranslated region of the transcri...

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Bibliographic Details
Main Authors: De-Liang eZhang, Manik C. Ghosh, Tracey A. Rouault
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Pharmacology
Subjects:
Erythropoiesis
Polycythemia
iron metabolism
pulmonary hypertension
Iron regulatory protein
iron responsive element
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00124/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00124/full

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