Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBPa) p42 versus p30 may contribute in part, to aberrant C/EBPa activity in acute leukemias

Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBPa) p42 versus p30 may contribute in part, to aberrant C/EBPa activity in acute leukemias

In this study, we have examined the role of post-translational modification of the myeloid master regulator C/EBP by small ubiquitin-related modifier (SUMO). We have used transient transfection analysis, oligonucleotide pulldown assays and chromatin immunoprecititation in all-trans retinoic acid (A...

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Bibliographic Details
Main Authors: William Hankey, Matthew Silver, Hong Sun, Terry Zibello, Nancy Berliner, Arati Khanna-Gupta
Format: Article
Language:English
Published: PAGEPress Publications 2011-05-01
Series:Hematology Reports
Subjects:
Myeloid transcription, Post-translational modification, leukemogenesis.
Online Access:http://www.pagepress.org/journals/index.php/hr/article/view/2402

Internet

http://www.pagepress.org/journals/index.php/hr/article/view/2402

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