Methotrexate-induced acute kidney injury in patients with hematological malignancies: three case reports with literature review

Methotrexate-induced acute kidney injury in patients with hematological malignancies: three case reports with literature review

Abstract Background High-dose methotrexate (HD-MTX) therapy has been used to treat a wide range of oncological malignancies. While the therapy can be tolerated with hydration, urine pH control, and leucovorin rescue therapy, HD-MTX is cytotoxic and can cause renal failure. There have been several ca...

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Bibliographic Details
Main Authors: Mineaki Kitamura, Satoko Kitamura, Machiko Fujioka, Rena Kamijo, Shinya Sato, Yasushi Sawayama, Tadashi Uramatsu, Yoko Obata, Yasushi Mochizuki, Masaharu Nishikido, Hideki Sakai, Yasushi Miyazaki, Hiroshi Mukae, Tomoya Nishino
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Renal Replacement Therapy
Subjects:
High-dose methotrexate
Acute kidney injury
Blood purification
Hematological malignancies
Online Access:http://link.springer.com/article/10.1186/s41100-018-0180-9

Internet

http://link.springer.com/article/10.1186/s41100-018-0180-9

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