PRESTO: Rapid calculation of order statistic distributions and multiple-testing adjusted P-values via permutation for one and two-stage genetic association studies

<p>Abstract</p> <p>Background</p> <p>Large-scale genetic association studies can test hundreds of thousands of genetic markers for association with a trait. Since the genetic markers may be correlated, a Bonferroni correction is typically too stringent a correction for...

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Bibliographic Details
Main Author: Browning Brian L
Format: Article
Language:English
Published: BMC 2008-07-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/9/309