DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation

DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation

Tight regulation of inflammatory cytokine and interferon (IFN) production in innate immunity is pivotal for optimal control of pathogens and avoidance of immunopathology. The human Nod-like receptor (NLR) NLRP11 has been shown to regulate type I IFN and pro-inflammatory cytokine responses. Here, we...

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Bibliographic Details
Main Authors: Ioannis Kienes, Sarah Bauer, Clarissa Gottschild, Nora Mirza, Jens Pfannstiel, Martina Schröder, Thomas A. Kufer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
innate immunity
nod-like receptors
anti-viral
DEAD-box helicase
inflammasome
IL-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.653883/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.653883/full

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