Genetic adjuvantation of recombinant MVA with CD40L potentiates CD8 T cell mediated immunity

Genetic adjuvantation of recombinant MVA with CD40L potentiates CD8 T cell mediated immunity

Modified vaccinia Ankara (MVA) is a safe and promising viral vaccine vector that is currently investigated in several clinical and pre-clinical trials. In contrast to inactivated or sub-unit vaccines, MVA is able to induce strong humoral as well as cellular immune responses. In order to further impr...

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Bibliographic Details
Main Authors: Henning eLauterbach, Juliane ePätzold, Ronny eKassub, Barbara eBathke, Kay eBrinkmann, Paul eChaplin, Mark eSuter, Hubertus eHochrein
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Immunology
Subjects:
Ectromelia virus
Vaccination
Viral Vaccines
CD8 T cells
T cell memory
CD40L
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00251/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00251/full

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