Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer’s Disease Pathology and Shows Differential Expression in Transgenic Mice

Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer’s Disease Pathology and Shows Differential Expression in Transgenic Mice

There is increasing evidence that metabolic dysfunction plays an important role in Alzheimer’s disease (AD). Brain insulin resistance and subsequent impairment of insulin and insulin-like growth factor (IGF) signaling are associated with the neurodegenerative and clinical features of AD. Nevertheles...

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Bibliographic Details
Main Authors: Luke W. Bonham, Ethan G. Geier, Natasha Z. R. Steele, Dominic Holland, Bruce L. Miller, Anders M. Dale, Rahul S. Desikan, Jennifer S. Yokoyama, Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Neuroscience
Subjects:
IGFBP-2
Alzheimer’s disease
CSF
neuroimaging
tau
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00476/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00476/full

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