Structural and electrophysiological dysfunctions due to increased endoplasmic reticulum stress in a long-term pacing model using human induced pluripotent stem cell-derived ventricular cardiomyocytes

Structural and electrophysiological dysfunctions due to increased endoplasmic reticulum stress in a long-term pacing model using human induced pluripotent stem cell-derived ventricular cardiomyocytes

Abstract Background Long-term ventricular pacing has deleterious effects and becomes more significant when cumulative percent ventricular pacing (Cum%VP) exceeds 40% of time. However, cellular disturbances and pathways by which pacing leads to myocardial disorders are not well understood. Attempts t...

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Bibliographic Details
Main Authors: Chang Cui, Le Geng, Jiaojiao Shi, Yue Zhu, Gang Yang, Zidun Wang, Jiaxian Wang, Minglong Chen
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Stem Cell Research & Therapy
Subjects:
Pace
Induced pluripotent stem cells
Electrophysiology
ER stress
Online Access:http://link.springer.com/article/10.1186/s13287-017-0566-6

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http://link.springer.com/article/10.1186/s13287-017-0566-6

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