Overexpression of <it>eIF-5A2 </it>in mice causes accelerated organismal aging by increasing chromosome instability

Overexpression of <it>eIF-5A2 </it>in mice causes accelerated organismal aging by increasing chromosome instability

<p>Abstract</p> <p>Background</p> <p>Amplification of 3q26 is one of the most frequent genetic alterations in many human malignancies. Recently, we isolated a novel oncogene <it>eIF-5A2 </it>within the 3q26 region. Functional study has demonstrated the oncog...

Full description

Bibliographic Details
Main Authors: Chen Leilei, Huen Michael SY, Tsang Sze, Deng Wen, Dong Suisui, Deng Hong, Huang Jian-Dong, Chen Muhan, Zan Tong, Zhu Gui-Xia, Guan Xin-Yuan
Format: Article
Language:English
Published: BMC 2011-05-01
Series:BMC Cancer
Subjects:
<it>eIF-5A2</it>
aging
chromosome instability
transgenic mouse
oncogene
Online Access:http://www.biomedcentral.com/1471-2407/11/199

Internet

http://www.biomedcentral.com/1471-2407/11/199

Similar Items