Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K<sub>2</sub>P Channels

Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K<sub>2</sub>P Channels

Two-pore domain potassium (K<sub>2</sub>P) channels maintain the cell&#8217;s background conductance by stabilizing the resting membrane potential. They assemble as dimers possessing four transmembrane helices in each subunit. K<sub>2</sub>P channels were crystallized in...

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Bibliographic Details
Main Authors: Daniel Bustos, Mauricio Bedoya, David Ramírez, Guierdy Concha, Leandro Zúñiga, Niels Decher, Erix W. Hernández-Rodríguez, Francisco V. Sepúlveda, Leandro Martínez, Wendy González
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
k<sub>2</sub>p channels
task-2 channels
structure–function relationships
homology modeling
modeling of protein dynamics
Online Access:https://www.mdpi.com/1422-0067/21/2/532

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https://www.mdpi.com/1422-0067/21/2/532

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