Single Cell Transcriptomics Reveal Abnormalities in Neurosensory Patterning of the Chd7 Mutant Mouse Ear

Single Cell Transcriptomics Reveal Abnormalities in Neurosensory Patterning of the Chd7 Mutant Mouse Ear

The chromatin remodeling protein CHD7 is critical for proper formation of the mammalian inner ear. Humans with heterozygous pathogenic variants in CHD7 exhibit CHARGE syndrome, characterized by hearing loss and inner ear dysplasia, including abnormalities of the semicircular canals and Mondini malfo...

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Bibliographic Details
Main Authors: Robert Durruthy-Durruthy, Ethan D. Sperry, Margot E. Bowen, Laura D. Attardi, Stefan Heller, Donna M. Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Genetics
Subjects:
CHD7
chromatin remodeling
inner ear development
single cell genomics
otic vesicle
mouse models
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00473/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00473/full

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