Targeting human epidermal growth factor receptor 2 enhances radiosensitivity and reduces the metastatic potential of Lewis lung carcinoma cells

Targeting human epidermal growth factor receptor 2 enhances radiosensitivity and reduces the metastatic potential of Lewis lung carcinoma cells

Abstract Background Sublethal radiation induces matrix metalloproteinase 9 (MMP-9)-mediated radioresistance in Lewis lung carcinoma (LLC) cells and their metastatic dissemination. We aim to determine if EGFR/HER2 activation associates with MMP-9-mediated radioresistance and invasiveness in irradiate...

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Bibliographic Details
Main Authors: Yun Tien, Chiao-Ling Tsai, Wei-Hsien Hou, Yun Chiang, Feng-Ming Hsu, Yu-Chieh Tsai, Jason Chia-Hsien Cheng
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Radiation Oncology
Subjects:
Human epidermal growth factor receptor 2
Lung cancer
Radiotherapy
Afatinib
MMP-9
Online Access:http://link.springer.com/article/10.1186/s13014-020-01493-8

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http://link.springer.com/article/10.1186/s13014-020-01493-8

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