Evaluation of Methylation Biomarkers for Detection of Circulating Tumor DNA and Application to Colorectal Cancer

Evaluation of Methylation Biomarkers for Detection of Circulating Tumor DNA and Application to Colorectal Cancer

Solid tumors shed DNA into circulation, and there is growing evidence that the detection of circulating tumor DNA (ctDNA) has broad clinical utility, including monitoring of disease, prognosis, response to chemotherapy and tracking tumor heterogeneity. The appearance of ctDNA in the circulating cell...

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Bibliographic Details
Main Authors: Susan M. Mitchell, Thu Ho, Glenn S. Brown, Rohan T. Baker, Melissa L. Thomas, Aidan McEvoy, Zheng-Zhou Xu, Jason P. Ross, Trevor J. Lockett, Graeme P. Young, Lawrence C. LaPointe, Susanne K. Pedersen, Peter L. Molloy
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Genes
Subjects:
hypermethylation
biomarkers
colorectal cancer
plasma
BCAT1
GRASP
IKZF1
IRF4 SDC2
SEPT9
epigenetics
circulating tumor DNA
liquid biopsy
Online Access:http://www.mdpi.com/2073-4425/7/12/125

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http://www.mdpi.com/2073-4425/7/12/125

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