Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway

Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway

Abstract Background Drug resistance is common in cancer chemotherapy. This study investigates the role of Glycerol kinase 5 (GK5) in mediating gefitinib resistance in NSCLC. Methods The exosomal mRNA of GK5 was detected using a tethered cationic lipoplex nanoparticle (TCLN) biochip. Real-time PCR an...

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Bibliographic Details
Main Authors: Jian Zhou, Guimei Qu, Ge Zhang, Zuoren Wu, Jing Liu, Dawei Yang, Jing Li, Meijia Chang, Hengshan Zeng, Jie Hu, Tao Fang, Yuanlin Song, Chunxue Bai
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Non-small cell lung cancer
Glycerol kinase 5
Gefitinib
Stearoyl-CoA desaturase-1
Online Access:http://link.springer.com/article/10.1186/s13046-019-1057-7

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http://link.springer.com/article/10.1186/s13046-019-1057-7

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