Metabolic Perturbations Caused by the Over-Expression of mcr-1 in Escherichia coli

Metabolic Perturbations Caused by the Over-Expression of mcr-1 in Escherichia coli

Rapid dissemination of the plasmid-born polymyxin resistance gene mcr-1 poses a critical medical challenge. MCR-1 expression is tightly controlled and imposes a fitness cost on the bacteria. We used growth studies and metabolomics to examine growth and metabolic changes within E. coli TOP10 at 8 and...

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Bibliographic Details
Main Authors: Yi-Yun Liu, Yan Zhu, Hasini Wickremasinghe, Phillip J. Bergen, Jing Lu, Xiao-Qing Zhu, Qiao-Li Zhou, Mohammad Azad, Sue C. Nang, Mei-Ling Han, Tao Lei, Jian Li, Jian-Hua Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Microbiology
Subjects:
colistin
mcr-1
fitness cost
metabolomics
glycerophospholipids
pentose phosphate pathway
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.588658/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.588658/full

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