The tyrosine kinase c-Abl potentiates interferon-mediated antiviral immunity by STAT1 phosphorylation

The tyrosine kinase c-Abl potentiates interferon-mediated antiviral immunity by STAT1 phosphorylation

Summary: Interferon (IFN)-induced activation of the signal transducer and activator of transcription (STAT) family is an important event in antiviral immunity. Here, we show that the nonreceptor kinases c-Abl and Arg directly interact with STAT1 and potentiate the phosphorylation of STAT1 on Y701. c...

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Bibliographic Details
Main Authors: Hainan Liu, Yan Cui, Yu Bai, Yi Fang, Ting Gao, Guangfei Wang, Lin Zhu, Qincai Dong, Shuwei Zhang, Yi Yao, Caiwei Song, Xiayang Niu, Yanwen Jin, Ping Li, Cheng Cao, Xuan Liu
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:iScience
Subjects:
Biological Sciences
Virology
Viral Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221000468

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http://www.sciencedirect.com/science/article/pii/S2589004221000468

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