A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

A highly efficacious pre-erythrocytic stage vaccine would be an important tool for the control and elimination of malaria but is currently unavailable. High-level protection in humans can be achieved by experimental immunization with Plasmodium falciparum sporozoites attenuated by radiation or under...

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Bibliographic Details
Main Authors: Ben C L van Schaijk, Ivo H J Ploemen, Takeshi Annoura, Martijn W Vos, Lander Foquet, Geert-Jan van Gemert, Severine Chevalley-Maurel, Marga van de Vegte-Bolmer, Mohammed Sajid, Jean-Francois Franetich, Audrey Lorthiois, Geert Leroux-Roels, Philip Meuleman, Cornelius C Hermsen, Dominique Mazier, Stephen L Hoffman, Chris J Janse, Shahid M Khan, Robert W Sauerwein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
Plasmodium
sporozoite
genetically attenuated parasite
malaria
vaccine
Online Access:https://elifesciences.org/articles/03582

Internet

https://elifesciences.org/articles/03582

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