ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming

ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming

Summary: T cells are strongly regulated by oxidizing environments and amino acid restriction. How T cells reprogram metabolism to adapt to these extracellular stress situations is not well understood. Here, we show that oxidizing environments and amino acid starvation induce ATF4 in CD4+ T cells. We...

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Bibliographic Details
Main Authors: Xi Yang, Rui Xia, Cuihua Yue, Wensi Zhai, Wenwen Du, Qianting Yang, Huiling Cao, Xiaojuan Chen, Danielle Obando, Yibei Zhu, Xinchun Chen, Jane-Jane Chen, Jon Piganelli, Peter Wipf, Yu Jiang, Guozhi Xiao, Changping Wu, Jingting Jiang, Binfeng Lu
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471830576X

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http://www.sciencedirect.com/science/article/pii/S221112471830576X

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