Inherited selective cobalamin malabsorption in Komondor dogs associated with a CUBN splice site variant

Inherited selective cobalamin malabsorption in Komondor dogs associated with a CUBN splice site variant

Abstract Background Three Komondor dogs in a small family and 3 sporadic cases exhibited a constellation of signs that included juvenile-onset of failure-to-thrive, inappetence, vomiting and/or diarrhea, and weakness. In each we documented dyshematopoiesis, increased anion gap, methylmalonic acidemi...

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Bibliographic Details
Main Authors: John C. Fyfe, Shelby L. Hemker, Alycia Frampton, Karthik Raj, Peter L. Nagy, Kristi J. Gibbon, Urs Giger
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Veterinary Research
Subjects:
Vitamin B12
Amnionless
Cubilin
Inborn error of metabolism
Methylmalonic aciduria
Animal model
Online Access:http://link.springer.com/article/10.1186/s12917-018-1752-1

Internet

http://link.springer.com/article/10.1186/s12917-018-1752-1

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