Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan

Pharmacometabolomics has been already successfully used in toxicity prediction for one specific adverse effect. However in clinical practice, two or more different toxicities are always accompanied with each other, which puts forward new challenges for pharmacometabolomics. Gastrointestinal toxicity...

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Bibliographic Details
Main Authors: Yiqiao Gao, Wei Li, Jiaqing Chen, Xu Wang, Yingtong Lv, Yin Huang, Zunjian Zhang, Fengguo Xu
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Acta Pharmaceutica Sinica B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383518304453