Thrombin Contributes to Anti-myeloperoxidase Antibody Positive IgG-Mediated Glomerular Endothelial Cells Activation Through SphK1-S1P-S1PR3 Signaling

Thrombin Contributes to Anti-myeloperoxidase Antibody Positive IgG-Mediated Glomerular Endothelial Cells Activation Through SphK1-S1P-S1PR3 Signaling

Background: Activation of coagulation system plays an important role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) pathogenesis. Thrombin, generated during coagulation could disrupt endothelial barrier integrity through protease-activated receptor 1 (PAR1). Our previous s...

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Bibliographic Details
Main Authors: Xiao-Jing Sun, Min Chen, Ming-Hui Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
ANCA
vasculitis
thrombin
sphingosine-1-phosphate
endothelium
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00237/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00237/full

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