Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency.

Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency.

The mitochondrion is emerging as a key organelle in stem cell biology, acting as a regulator of stem cell pluripotency and differentiation. In this study we sought to understand the effect of mitochondrial complex III inhibition during neuronal differentiation of mouse embryonic stem cells. When exp...

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Bibliographic Details
Main Authors: Sandro L Pereira, Mário Grãos, Ana Sofia Rodrigues, Sandra I Anjo, Rui A Carvalho, Paulo J Oliveira, Ernest Arenas, João Ramalho-Santos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3847032?pdf=render

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http://europepmc.org/articles/PMC3847032?pdf=render

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