Rapamycin Preserves Neural Tissue, Promotes Schwann Cell Myelination and Reduces Glial Scar Formation After Hemi-Contusion Spinal Cord Injury in Mice

Rapamycin Preserves Neural Tissue, Promotes Schwann Cell Myelination and Reduces Glial Scar Formation After Hemi-Contusion Spinal Cord Injury in Mice

Protecting white matter is one of the key treatment strategies for spinal cord injury (SCI), including alleviation of myelin loss and promotion of remyelination. Rapamycin has been shown neuroprotective effects against SCI and cardiotoxic effects while enhancing autophagy. However, specific neuropro...

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Bibliographic Details
Main Authors: Junhao Liu, Ruoyao Li, Zucheng Huang, Junyu Lin, Wei Ji, Zhiping Huang, Qi Liu, Xiaoliang Wu, Xiuhua Wu, Hui Jiang, Yongnong Ye, Qingan Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autophagy
spinal cord injury
rapamycin
Schwann cells
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2020.574041/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2020.574041/full

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