BMSC-Exosomes Carry Mutant HIF-1α for Improving Angiogenesis and Osteogenesis in Critical-Sized Calvarial Defects

BMSC-Exosomes Carry Mutant HIF-1α for Improving Angiogenesis and Osteogenesis in Critical-Sized Calvarial Defects

Repair and reconstruction of critical-sized bone defects has always been a difficult task in orthopedics. Hypoxia inducible factor-1α (HIF-1α) plays an important role in bone defect repair, it has the dual function of promoting osteogenesis and vascular regeneration, but it is quickly degraded by th...

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Bibliographic Details
Main Authors: Chenting Ying, Rui Wang, Zhenlin Wang, Jie Tao, Wenjing Yin, Jieyuan Zhang, Chengqing Yi, Xin Qi, Dan Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
BMSC-Exos-HIF1α
bone defects
osteogenesis
vascularization
β-TCP scaffolds
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.565561/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2020.565561/full

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