Macrocycle Therapeutics to Treat Life-threatening Diseases

Polyphor's macrocycle platform led to the discovery of novel antibiotics addressing specifically Gramnegative bacteria by targeting outer membrane proteins. Furthermore, POL6014, an inhibitor of neutrophile elastase and balixafortide, a CXCR4 inhibitor have been discovered and developed from th...

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Bibliographic Details
Main Authors: Gokhan Batur, Philipp Ermert, Johann Zimmermann, Daniel Obrecht
Format: Article
Language:deu
Published: Swiss Chemical Society 2021-06-01
Series:CHIMIA
Subjects:
Online Access:https://www.ingentaconnect.com/contentone/scs/chimia/2021/00000075/00000006/art00009