The protective effect against extracellular histones afforded by long-pentraxin PTX3 as a regulator of NETs

Pentraxin 3 (PTX3) is a soluble pattern recognition molecule which plays critical roles in innate immunity. Its fundamental functions include recognition of microbes, activation of complement cascades and opsonization. The findings that PTX3 is one of the component proteins in neutrophil extracellul...

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Bibliographic Details
Main Authors: Kenji Daigo, Yuichiro Takamatsu, Takao Hamakubo
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00344/full