STAT5 is an ambivalent regulator of neutrophil homeostasis.

STAT5 is an ambivalent regulator of neutrophil homeostasis.

BACKGROUND: Although STAT5 promotes survival of hematopoietic progenitors, STAT5-/- mice develop mild neutrophilia. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that in STAT5-/- mice, liver endothelial cells (LECs) autonomously secrete high amounts of G-CSF, allowing myeloid progenitors to overcomp...

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Bibliographic Details
Main Authors: Laurence Fiévez, Christophe Desmet, Emmanuelle Henry, Bernard Pajak, Silke Hegenbarth, Virginie Garzé, Françoise Bex, Fabrice Jaspar, Philippe Boutet, Laurent Gillet, Alain Vanderplasschen, Percy A Knolle, Oberdan Leo, Muriel Moser, Pierre Lekeux, Fabrice Bureau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1939728?pdf=render

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http://europepmc.org/articles/PMC1939728?pdf=render

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