Investigation of Combined Cyclodextrin and Hydrogel Formulation for Ocular Delivery of Dexamethasone Acetate by Means of Experimental Designs

Investigation of Combined Cyclodextrin and Hydrogel Formulation for Ocular Delivery of Dexamethasone Acetate by Means of Experimental Designs

Dexamethasone acetate (DXMa) has proven its efficiency to treat corneal inflammation, without a great propensity to increase intraocular pressure. Unfortunately, its poor aqueous solubility, associated with a rapid precorneal elimination, results in a low drug bioavailability and a low penetration a...

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Bibliographic Details
Main Authors: Roseline Mazet, Luc Choisnard, Delphine Levilly, Denis Wouessidjewe, Annabelle Gèze
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceutics
Subjects:
dexamethasone acetate
cyclodextrins
eye drops
hydrogels
experimental design
phase solubility
dissolution assay
Online Access:https://www.mdpi.com/1999-4923/10/4/249

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https://www.mdpi.com/1999-4923/10/4/249

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