A Hydroquinone-Based Derivative Elicits Apoptosis and Autophagy via Activating a ROS-Dependent Unfolded Protein Response in Human Glioblastoma

A Hydroquinone-Based Derivative Elicits Apoptosis and Autophagy via Activating a ROS-Dependent Unfolded Protein Response in Human Glioblastoma

5-Lipoxygenase (5-LO) has been reported to be highly expressed in brain tumors and to promote glioma cell proliferation. Therefore, we investigated the anticancer activity of the novel 5-LO inhibitor derivative 3-tridecyl-4,5-dimethoxybenzene-1,2-diol hydroquinone (EA-100C red) on glioblastoma (GBM)...

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Bibliographic Details
Main Authors: Silvia Zappavigna, Alessia Maria Cossu, Marianna Abate, Gabriella Misso, Angela Lombardi, Michele Caraglia, Rosanna Filosa
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
anticancer drug
apoptosis
autophagy
ER stress
natural compound
reactive oxygen species (ROS)
Online Access:https://www.mdpi.com/1422-0067/20/15/3836

Internet

https://www.mdpi.com/1422-0067/20/15/3836

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