Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression

<p>Abstract</p> <p>Cancer precursor/progenitor cells may initiate and sustain the growth of tumors, but evidence for their existence in human disease is indirect, relying on their <it>in vitro </it>properties and animal models. More directly, specific elimination of the...

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Bibliographic Details
Main Authors: Goodell Margaret A, Andreeff Michael, Carrum George, Savoldo Barbara, Yvon Eric, Dotti Gianpietro, Lu An, Biagi Ettore, Okur Fatma V, Foster Aaron E, Heslop Helen E, Brenner Malcolm K
Format: Article
Language:English
Published: BMC 2009-11-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/8/1/106