Dihydropyrimidine dehydrogenase gene variation and its association with 5-fluorouracil toxicity in colorectal patients

Dihydropyrimidine dehydrogenase gene variation and its association with 5-fluorouracil toxicity in colorectal patients

Purpose: Dihydropyrimidine dehydrogenase (DPD), an enzyme translated by DPD gene (DPYD), has a critical role in the metabolism of 5-fluorouracil (5FU). In this study we aimed to investigate the frequency of the IVS14+1 G>A, 2194G>A, 2846 A>T mutations in the DPYD gene in colorectal cancer p...

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Bibliographic Details
Main Authors:	ebrahim salehifar, Mohammad Javad Abd Haghighi, Reza Negarande, Ghasem Janbabaei, fateme safgafi, hossein jalali
Format:	Article
Language:	English
Published:	West Asia Organization for Cancer Prevention 2018-09-01
Series:	Asian Pacific Journal of Cancer Biology
Online Access:	http://www.waocp.org/journal/index.php/apjcb/article/view/142

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