AOS ameliorates monocrotaline-induced pulmonary hypertension by restraining the activation of P-selectin/p38MAPK/NF-κB pathway in rats

AOS ameliorates monocrotaline-induced pulmonary hypertension by restraining the activation of P-selectin/p38MAPK/NF-κB pathway in rats

Perivascular inflammation, vascular luminal area reduction and hemodynamics changes are important pathophysiologic bases of pulmonary hypertension (PH). In this study, PH was induced by an intraperitoneal single injection of monocrotaline (MCT, 60 mg/kg). Alginate oligosaccharides (AOS), one of the...

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Bibliographic Details
Main Authors: Yi Hu, Zhe Feng, Wenjing Feng, Ting Hu, Huashi Guan, Yongjun Mao
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Alginate oligosaccharides
Pulmonary hypertension
Monocrotaline
Inflammation
P-selectin
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218344548

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http://www.sciencedirect.com/science/article/pii/S0753332218344548

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