Comparison of sequencing methods and data processing pipelines for whole genome sequencing and minority single nucleotide variant (mSNV) analysis during an influenza A/H5N8 outbreak.

Comparison of sequencing methods and data processing pipelines for whole genome sequencing and minority single nucleotide variant (mSNV) analysis during an influenza A/H5N8 outbreak.

As high-throughput sequencing technologies are becoming more widely adopted for analysing pathogens in disease outbreaks there needs to be assurance that the different sequencing technologies and approaches to data analysis will yield reliable and comparable results. Conversely, understanding where...

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Bibliographic Details
Main Authors: Marjolein J Poen, Anne Pohlmann, Clara Amid, Theo M Bestebroer, Sharon M Brookes, Ian H Brown, Helen Everett, Claudia M E Schapendonk, Rachel D Scheuer, Saskia L Smits, Martin Beer, Ron A M Fouchier, Richard J Ellis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229326

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https://doi.org/10.1371/journal.pone.0229326

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