Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia.

Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia.

The epigenetic impact of DNA methylation in chronic myelogenous leukemia (CML) is not completely understood. To elucidate its role we analyzed 120 patients with CML for methylation of promoter-associated CpG islands of 10 genes. Five genes were identified by DNA methylation screening in the K562 cel...

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Bibliographic Details
Main Authors: Jaroslav Jelinek, Vazganush Gharibyan, Marcos R H Estecio, Kimie Kondo, Rong He, Woonbok Chung, Yue Lu, Nianxiang Zhang, Shoudan Liang, Hagop M Kantarjian, Jorge E Cortes, Jean-Pierre J Issa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3132778?pdf=render

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http://europepmc.org/articles/PMC3132778?pdf=render

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