Elevated Granzyme B in cytotoxic lymphocytes is a signature of immune activation in hemophagocytic lymphohistiocytosis

Patients with hemophagocytic lymphohistiocytosis (HLH) exhibit immune hyper-activation as a consequence of genetic defects in secretory granule proteins of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Murine models of HLH demonstrate significant activation of CTL as central to the di...

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Bibliographic Details
Main Authors: Sabine eMellor-Heineke, Joyce eVillanueva, Michael B Jordan, Rebecca eMarsh, Kejian eZhang, Jack eBleesing, Alexandra (Lisa) H Filipovich, Kimberly A Risma
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-03-01
Series:Frontiers in Immunology
Subjects:
CTL
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00072/full