Bile Acids Activate YAP to Promote Liver Carcinogenesis

Bile Acids Activate YAP to Promote Liver Carcinogenesis

Elevated bile acid levels increase hepatocellular carcinoma by unknown mechanisms. Here, we show that mice with a severe defect in bile acid homeostasis due to the loss of the nuclear receptors FXR and SHP have enlarged livers, progenitor cell proliferation, and Yes-associated protein (YAP) activat...

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Bibliographic Details
Main Authors: Sayeepriyadarshini Anakk, Manoj Bhosale, Valentina A. Schmidt, Randy L. Johnson, Milton J. Finegold, David D. Moore
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713006141

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http://www.sciencedirect.com/science/article/pii/S2211124713006141

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