Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN

Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN

The innate immune and host-protective responses to viruses, such as the airway pathogen human metapneumovirus (HMPV), depend on interferons (IFNs) that is induced through TANK-binding kinase 1 (TBK1) and IFN regulatory factors (IRFs). The transcription factor IRF1 is important for host resistance ag...

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Bibliographic Details
Main Authors: Simon Loevenich, Alix S. Spahn, Kristin Rian, Victor Boyartchuk, Marit Walbye Anthonsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
human macrophages
innate immune response
antiviral response
interferon
human metapneumovirus
interferon regulatory factor 1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.563336/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.563336/full

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