Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report

• Main Authors: Christopher Trosclair, Maressa Pollen, Gerald Capraro, James Cotelingam, Rodney E. Shackelford
• Format: Article
• Language: English
• Published: Karger Publishers 2014-06-01
• Series: Case Reports in Oncology
• Subjects: Acute myelogenous leukemia without maturation; PML/RAR?; Deletion; t(15;17)(q22;q21); Acute promyelocytic leukemia; AML-M3; AML-M1
• Online Access: http://www.karger.com/Article/FullText/365002

Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML) subtypes. Rare complex APL genomic rearrangements have retinoic acid alpha-receptor sequence deletions. Here we report a retinoic acid alpha-receptor sequence deletion in a case of AML without differentiation. To our knowledge, this is the first example of a retinoic acid alpha-receptor sequence deletion in this AML subtype.