Cytokines and growth factors cross-link heparan sulfate

Cytokines and growth factors cross-link heparan sulfate

The glycosaminoglycan heparan sulfate (HS), present at the surface of most cells and ubiquitous in extracellular matrix, binds many soluble extracellular signalling molecules such as chemokines and growth factors, and regulates their transport and effector functions. It is, however, unknown whether...

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Bibliographic Details
Main Authors: Elisa Migliorini, Dhruv Thakar, Jens Kühnle, Rabia Sadir, Douglas P. Dyer, Yong Li, Changye Sun, Brian F. Volkman, Tracy M. Handel, Liliane Coche-Guerente, David G. Fernig, Hugues Lortat-Jacob, Ralf P. Richter
Format: Article
Language:English
Published: The Royal Society 2015-01-01
Series:Open Biology
Subjects:
heparan sulfate
glycosaminoglcyan
extracellular matrix
chemokine
growth factor
cytokine
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150046

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150046

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