Memory Impairment and Reduced Exploratory Behavior in Mice after Administration of Systemic Morphine

Memory Impairment and Reduced Exploratory Behavior in Mice after Administration of Systemic Morphine

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In the present study, the effects of morphine were examined on tests of spatial memory, object exploration, locomotion, and anxiety in male ICR mice. Administration of morphine (15 or 30 mg/kg, intraperitoneally (i.p.)) induced a significant decrease in Y-maze alternations compared to saline vehicle...

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Bibliographic Details
Main Authors: Junichi Kitanaka, Nobue Kitanaka, F. Scott Hall, Mei Fujii, Akiko Goto, Yusuke Kanda, Akira Koizumi, Hirotoshi Kuroiwa, Satoko Mibayashi, Yumi Muranishi, Soichiro Otaki, Minako Sumikawa, Koh-Ichi Tanaka, Nobuyoshi Nishiyama, George R. Uhl, Motohiko Takemura
Format: Article
Language:English
Published: SAGE Publishing 2015-01-01
Series:Journal of Experimental Neuroscience
Online Access:https://doi.org/10.4137/JEN.S25057

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https://doi.org/10.4137/JEN.S25057

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