Association of HLA-G Low Expressor Genotype with Severe Acute Graft-versus-Host Disease after sibling Bone Marrow Transplantation

Association of HLA-G Low Expressor Genotype with Severe Acute Graft-versus-Host Disease after sibling Bone Marrow Transplantation

BackgroundHLA-G molecules play a prominent role in immune tolerance. Structurally similar to their classical HLA homologues, they are distinct by having high rate of polymorphism in the non-coding regions including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele in the...

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Bibliographic Details
Main Authors: Wahid eBoukouaci, Marc eBusson, Catherine eFortier, Kahina eAmokrane, Régis ePeffault de Latour, Marie eRobin, Rajagopal eKrishnamoorthy, Antoine eToubert, Dominique eCharron, Gérard eSocié, Ryad eTamouza
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Immunology
Subjects:
Hematopoietic Stem Cell Transplantation
acute GVHD
HLA-G polymorphism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00074/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00074/full

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