Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway

Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway

Microvessel hypoperfusion following ischemic stress resulted in a decreased shear stress of brain microvascular endothelial cells (BMECs) and contributed to abnormal expression of PECAM-1 after global cerebral ischemia/reperfusion (I/R) injury. Here, we identified novel pathophysiologic and rehabili...

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Bibliographic Details
Main Authors: Jing-Quan Gao, Peng Wang, Jun-Wei Yan, Li-Na Ba, Pi-Long Shi, Hong-Mei Wu, Xue-Ying Guan, Yong-gang Cao, Hong-Li Sun, Xiao-Yuan Mao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
global cerebral ischemia reperfusion injury
shear stress
PECAM-1
brain microvascular endothelial cells
nitric oxide
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.631286/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.631286/full

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