TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

Abstract The pathogenetic mechanisms underlying neuronal death and dysfunction in Alzheimer’s disease (AD) remain unclear. However, chronic neuroinflammation has been implicated in stimulating or exacerbating neuronal damage. The tumor necrosis factor (TNF) superfamily of cytokines are involved in m...

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Bibliographic Details
Main Authors: Anusha Jayaraman, Thein Than Htike, Rachel James, Carmen Picon, Richard Reynolds
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Acta Neuropathologica Communications
Subjects:
Necroptosis
Alzheimer’s disease
Post-mortem brain
iPSC
Tumor necrosis factor
ESCRT III
Online Access:https://doi.org/10.1186/s40478-021-01264-w

Internet

https://doi.org/10.1186/s40478-021-01264-w

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