Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis

Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis

Abstract Background Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. Although the involvement of connective tissue growth factor (CTGF/CCN2) has been well-documented in SSc fibrosis, the therapeutic potential of targeting CTGF in SSc has not been fully investiga...

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Bibliographic Details
Main Authors: Katsunari Makino, Tomoko Makino, Lukasz Stawski, Kenneth E. Lipson, Andrew Leask, Maria Trojanowska
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Arthritis Research & Therapy
Subjects:
Angiotensin II
CTGF/CCN2
FG-3019
Fibrosis
Skin
Systemic sclerosis
Online Access:http://link.springer.com/article/10.1186/s13075-017-1356-3

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http://link.springer.com/article/10.1186/s13075-017-1356-3

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