Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis

Immune responses to citrullinated peptides have been described in autoimmune diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS). We investigated the post-translational modification (PTM), arginine to citrulline, in brain tissue of MS patients and controls (C) by proteomics and subse...

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Bibliographic Details
Main Authors: Wolfgang Faigle, Carolina Cruciani, Witold Wolski, Bernd Roschitzki, Marco Puthenparampil, Paula Tomas-Ojer, Carla Sellés-Moreno, Thomas Zeis, Ivan Jelcic, Nicole Schaeren-Wiemers, Mireia Sospedra, Roland Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
human brain
multiple sclerosis
citrullination
T cell reactivity
autoimmune
proteomics
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00540/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00540/full

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