Reversal learning paradigm reveals deficits in cognitive flexibility in the Fmr1 knockout male mouse [version 1; referees: 1 approved, 2 approved with reservations]

Background: Loss of FMR1 is associated with Fragile X syndrome, amongst the most prevalent inherited intellectual disability. Despite extensive research in this area, previous studies have failed to detect consistent evidence of cognitive impairments in the Morris water maze (MWM) task in the Fmr1 k...

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Bibliographic Details
Main Authors: Suzanne O. Nolan, Joaquin N. Lugo
Format: Article
Language:English
Published: F1000 Research Ltd 2018-06-01
Series:F1000Research
Online Access:https://f1000research.com/articles/7-711/v1