Tetrodotoxin Blockade on Canine Cardiac L-Type Ca2+ Channels Depends on pH and Redox Potential

Tetrodotoxin Blockade on Canine Cardiac L-Type Ca2+ Channels Depends on pH and Redox Potential

Tetrodotoxin (TTX) is believed to be one of the most selective inhibitors of voltage-gated fast Na+ channels in excitable tissues. Recently, however, TTX has been shown to block L-type Ca2+ current (ICa) in canine cardiac cells. In the present study, the TTX-sensitivity of ICa was studied in isolate...

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Bibliographic Details
Main Authors: Bence Hegyi, István Komáromi, Kornél Kistamás, Ferenc Ruzsnavszky, Krisztina Váczi, Balázs Horváth, János Magyar, Tamás Bányász, Péter P. Nánási, Norbert Szentandrássy
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Marine Drugs
Subjects:
tetrodotoxin
calcium current
dog heart
pH dependence
redox potential
Online Access:http://www.mdpi.com/1660-3397/11/6/2140

Internet

http://www.mdpi.com/1660-3397/11/6/2140

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