Systemic activation of TLR3-dependent TRIF signaling confers host defense against Gram-negative bacteria in the intestine

Systemic activation of TLR3-dependent TRIF signaling confers host defense against Gram-negative bacteria in the intestine

Recognition of Gram-negative bacteria by toll-like receptor (TLR)4 induces MyD88 and TRIF mediated responses. We have shown that TRIF-dependent responses play an important role in intestinal defense against Gram-negative enteropathogens. In the current study, we examined underlying mechanisms of how...

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Bibliographic Details
Main Authors: Jose eRuiz, Saravana eKanagavelu, Claudia eFlores, Laura eRomero, Reldy eRiveron, David eShih, Masayuki eFukata
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Infection
innate immunity
intestine
Defense mechanism
TIR-domain-containing adapter-inducing interferon-β (TRIF)
natural killer cell.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00105/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00105/full

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