A versatile papaya mosaic virus (PapMV) vaccine platform based on sortase-mediated antigen coupling

A versatile papaya mosaic virus (PapMV) vaccine platform based on sortase-mediated antigen coupling

Abstract Background Flexuous rod-shaped nanoparticles made of the coat protein (CP) of papaya mosaic virus (PapMV) have been shown to trigger innate immunity through engagement of toll-like receptor 7 (TLR7). PapMV nanoparticles can also serve as a vaccine platform as they can increase the immune re...

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Bibliographic Details
Main Authors: Ariane Thérien, Mikaël Bédard, Damien Carignan, Gervais Rioux, Louis Gauthier-Landry, Marie-Ève Laliberté-Gagné, Marilène Bolduc, Pierre Savard, Denis Leclerc
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Nanobiotechnology
Subjects:
Papaya mosaic virus
Flexuous rod shape nanoparticles
Vaccine platform
Influenza M2e based vaccine
Sortase
Transpeptidase
Online Access:http://link.springer.com/article/10.1186/s12951-017-0289-y

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http://link.springer.com/article/10.1186/s12951-017-0289-y

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